Objectives Patients with heartburn and normal upper gastrointestinal endoscopy, normal
oesophageal acid exposure, no symptom-reflux association and who fail to respond to a
proton-pump inhibitor are classified as having functional heartburn (FH). This study aimed (i)
to characterize the symptoms and functional abnormalities of patients with FH and (ii) to
describe their clinical outcome. Materials and methods Among all patients referred for 24 h
multichannel intraluminal impedance-pH (MII-pH), patients with FH were identified. The …